How To Control Invega Sustenna Sexual Side Effects

Brand names:

Invega®
- Extended-release tablet: one.5 mg, 3 mg, half-dozen mg, nine mg
Invega Sustenna®
- Extended-release injectable suspension: 39 mg, 78 mg, 117 mg, 156 mg, 234 mg
Invega Trinza®
- Extended-release injectable suspension: 273mg, 410mg, 546mg, 819mg

Generic proper noun: paliperidone (pal ee PER i done)

All FDA black box warnings are at the end of this fact sheet. Please review before taking this medication.

What Is Paliperidone And What Does It Treat?

Paliperidone is a medication that works in the brain to treat schizophrenia and schizoaffective disorder. It is as well known equally a 2d-generation antipsychotic (SGA) or atypical antipsychotic. Paliperidone rebalances dopamine and serotonin to improve thinking, mood, and behavior.

Symptoms of schizophrenia/psychosis include:

Hallucinations — imagined voices or images that seem existent
Delusions — behavior that are not true (e.thousand., other people are reading your thoughts)
Disorganized thinking or problem organizing your thoughts and making sense
Footling desire to be around other people
Problem speaking clearly
Lack of motivation

Schizoaffective disorder is an disease that includes abnormal moods (elevated and/or depressed) and psychosis.

Mood symptoms include:

Depressed mood — feeling sad, empty, or bawling
Feeling worthless, guilty, hopeless, or helpless
Loss of interest or pleasance in normal activities
Slumber and swallow more or less than usual (for most people it is less)
Low energy, trouble concentrating, or thoughts of death (suicidal thinking)
Psychomotor agitation ('nervous free energy')
Psychomotor retardation (feeling similar you are moving in slow motion)
Feeling irritable or 'high"
Having increased self esteem
Feeling similar you lot don't demand to sleep
Feeling the demand to continue to talk
Feeling like your thoughts are too quick (racing thoughts)
Feeling distracted
Getting involved in activities that are risky or could have bad consequences (due east.g. excessive spending)

Paliperidone may help some or all of these symptoms.

This medication sail will focus primarily on schizophrenia. You tin find more than data nearly schizoaffective disorder hither.

What Is The Most Of import Data I Should Know About Paliperidone?

Schizophrenia requires long-term treatment. Practise not stop taking paliperidone, even when you feel better.

With input from you, your wellness intendance provider will assess how long you will demand to take the medicine.

Missing doses of paliperidone may increase your risk for a relapse in your symptoms.

Do not terminate taking paliperidone or alter your dose without talking with your healthcare provider first.

For paliperidone to work properly, information technology should be taken every day as ordered by your healthcare provider.

Are In that location Specific Concerns Most Paliperidone And Pregnancy?

If yous are planning on becoming pregnant, notify your healthcare provider to all-time manage your medications. People living with schizophrenia who wish to become pregnant face important decisions. This is a circuitous decision since untreated schizophrenia has risks to the fetus, also as the mother. It is important to discuss the risks and benefits of treatment with your medico and caregivers.

Antipsychotic use during the 3rd trimester of pregnancy has a run a risk for abnormal muscle movements (extrapyramidal symptoms [EPS]) and/or withdrawal symptoms in newborns following delivery. Symptoms in the newborn may include agitation, feeding disorder, hypertonia, hypotonia, respiratory distress, somnolence,and tremor; these effects may exist self-limiting or require hospitalization.

Circumspection is brash with breastfeeding since paliperidone does pass into chest milk.

What Should I Discuss With My Healthcare Provider Before Taking Paliperidone?

Symptoms of your condition that bother you lot the most
If y'all accept thoughts of suicide or harming yourself
Medications you have taken in the past for your condition, whether they were effective or caused whatever agin effects
If you ever had musculus stiffness, shaking, tardive dyskinesia, neuroleptic malignant syndrome, or weight proceeds caused by a medication
If you experience side effects from your medications, hash out them with your provider. Some side furnishings may pass with time, but others may require changes in the medication.
Whatsoever psychiatric or medical problems you have, such as middle rhythm bug, long QT syndrome, heart attacks, diabetes, high cholesterol, or seizures
If yous have a family history of diabetes or middle affliction
All other medications you are currently taking (including over the counter products, herbal and nutritional supplements) and whatsoever medication allergies you have
Other non-medication treatment you are receiving, such as talk therapy or substance abuse treatment. Your provider tin can explicate how these unlike treatments work with the medication.
If you are pregnant, programme to become pregnant, or are breast-feeding
If yous fume, potable alcohol, or use illegal drugs

How Should I Take Paliperidone?

Paliperidone tablets are commonly taken 1 time per day with or without food.

Typically patients begin at a depression dose of medicine and the dose is increased slowly over several weeks.

The dose of the tablets usually ranges from 3 mg to 12 mg. The dose of the Sustenna brand of long-acting paliperidone injection formulation usually ranges from 78 mg to 234 mg every month. The dose of the Trinza brand long-acting paliperidone injection formulation ranges from 273mg to 819mg every 3 months. But your healthcare provider can determine the correct dose for you lot.

The tablets should be swallowed whole. They should not be chewed, crushed, or cleaved.

Use a calendar, pillbox, alarm clock, or prison cell phone alert to help you remember to take your medication. You may also ask a family fellow member or a friend to remind you or bank check in with y'all to be sure you lot are taking your medication.

The Sustenna brand of long-interim injection paliperidone is administered twice in the first 8 days of treatment, then every four weeks. Your healthcare provider volition administer these injections.

What Happens If I Miss A Dose Of Paliperidone?

If you lot miss a dose of paliperidone, accept information technology as soon as yous remember, unless it is closer to the time of your next dose. Do not double your next dose or accept more than what is prescribed. If y'all miss an injection, telephone call your doctor or chemist correct away. Discuss this with your healthcare provider.

What Should I Avoid While Taking Paliperidone?

Avoid drinking alcohol or using illegal drugs while you are taking paliperidone. They may subtract the benefits (east.g. worsen your defoliation) and increase adverse effects (e.g. sedation) of the medication.

What Happens If I Overdose With Paliperidone?

If an overdose occurs phone call your doctor or 911. You may need urgent medical care. You may besides contact the poison control center at one-800-222-1222.

A specific treatment to contrary the effects of paliperidone does non exist.

What Are Possible Side Effects Of Paliperidone?

Common side effects

Tachycardia, drowsiness, extrapyramidal symptoms, restlessness, headache, increased prolactin, cholesterol abnormalities, increased glucose, vomiting, tremor

Rare/serious side effects

Paliperidone may increase the blood levels of a hormone called prolactin. Side furnishings of increased prolactin levels include females losing their period, production of chest milk and males losing their sexual practice drive or perchance experiencing erectile problems. Long term (months or years) of elevated prolactin tin lead to osteoporosis, or increased take a chance of bone fractures.

Some people may develop muscle related side effects while taking paliperidone. The technical terms for these are "extrapyramidal symptoms" (EPS) and "tardive dyskinesia" (TD). Symptoms of EPS include restlessness, tremor, and stiffness. TD symptoms include slow or jerky movements that 1 cannot command, ofttimes starting in the mouth with tongue rolling or chewing movements.

Temperature regulation: Dumb core trunk temperature regulation may occur; circumspection with strenuous practice, oestrus exposure, and dehydration.

Second generation antipsychotics (SGAs) increment the risk of weight gain, high blood sugar, and high cholesterol. This is as well known as metabolic syndrome. Your healthcare provider may ask you for a claret sample to bank check your cholesterol, blood sugar, and hemoglobin A1c (a measure of blood sugar over time) while you take this medication.

Information on good for you eating and calculation exercise to subtract your chances of developing metabolic syndrome may exist constitute at the post-obit sites:

http://www.helpguide.org/articles/good for you-eating/healthy-eating.htm
http://www.helpguide.org/abode-pages/exercise-fitness.htm

SGAs accept been linked with higher risk of death, strokes, and transient ischemic attacks (TIAs) in elderly people with beliefs problems due to dementia.

All antipsychotics have been associated with the adventure of sudden cardiac death due to an arrhythmia (irregular heartbeat). To minimize this risk, antipsychotic medications should be used in the smallest constructive dose when the benefits outweigh the risks. Your doctor may club an EKG to monitor for irregular heartbeat.

Neuroleptic malignant syndrome is a rare, life threatening adverse effect of antipsychotics which occurs in <1% of patients. Symptoms include defoliation, fever, extreme muscle stiffness, and sweating. If any of these symptoms occur, contact your healthcare provider immediately.

All antipsychotics can crusade sedation, dizziness, or orthostatic hypotension (a drop in blood pressure when standing up from sitting or lying downward). These side furnishings may atomic number 82 to falls which could cause bone fractures or other injuries. This risk is higher for people with conditions or other medications that could worsen these effects. If falls or any of these symptoms occur, contact your healthcare provider.

Are There Whatsoever Risks For Taking Paliperidone For Long Periods Of Time?

Tardive dyskinesia (TD) is a side outcome that develops with prolonged employ of antipsychotics. Medications such every bit paliperidone have been shown to accept a lower risk of TD compared to older antipsychotics, such every bit Haldol® (haloperidol). If you develop symptoms of TD, such every bit grimacing, sucking, and smacking of lips, or other movements that you lot cannot control, contact your healthcare provider immediately. All patients taking either showtime or second generation antipsychotics should accept an Abnormal Involuntary Movement Scale (AIMS) completed regularly by their healthcare provider to monitor for TD.

Second generation antipsychotics (SGAs) increase the chance of diabetes, weight gain, high cholesterol, and high triglycerides. (See "Serious Side Effects" section for monitoring recommendations).

What Other Medications May Collaborate With Paliperidone?

Paliperidone may cake the effects of agents used to treat Parkinson's disease such as levodopa (Sinemet®), bromocriptine, pramipexole (Mirapex®), ropinirole (Requip®), and others.

Paliperidone may lower your blood pressure level. Medications used to lower blood pressure may increase this effect and increase your chance of falling. Propranolol (Inderal®) is an example of this type of medication.

The post-obit medications may increase the risk of heart problems when used with paliperidone.

Antipsychotics including chlorpromazine (Thorazine®), thioridizine (Mellaril®), iloperidone (Fanapt®), asenapine (Saphris®), quetiapine (Seroquel®), and ziprasidone (Geodon®).
Antiarrhythmics (heart rhythm medications), including procainamide, quinidine, amiodarone (Cordarone®), dronedarone (Multaq®), and sotalol (Betapace®).

The following medications may increment the levels and effects of paliperidone: divalproex sodium (Depakote®).

The following medications may subtract the levels and furnishings of paliperidone: carbamazepine (Tegretol®, Equatro®), rifampin, St. John's Wort.

How Long Does It Take For Paliperidone To Piece of work?

It is very important to tell your doctor how you feel things are going during the kickoff few weeks subsequently yous start taking paliperidone. Information technology will probably accept several weeks to see big enough changes in your symptoms to decide if paliperidone is the right medication for you.

Antipsychotic treatment is generally needed lifelong for persons with schizophrenia. Your doc can all-time hash out the duration of handling you need based on your symptoms and illness.

Hallucinations, disorganized thinking, and delusions may better in the first one-ii weeks
Sometimes these symptoms practice not completely become abroad
Motivation and want to be around other people can take at least 1-ii weeks to improve
Symptoms go on to get better the longer y'all have paliperidone
It may take 2-3 months before you get the full do good of paliperidone

Summary of FDA Black Box Warnings

Increased mortality in elderly patients with dementia-related psychosis

Both commencement generation (typical) and second generation (singular) antipsychotics are associated with an increased risk of mortality in elderly patients when used for dementia related psychosis.
Although there were multiple causes of expiry in studies, about deaths appeared to be due to cardiovascular causes (due east.g. sudden cardiac decease) or infection (e.m. pneumonia).
Antipsychotics are not indicated for the handling of dementia-related psychosis.

Provided by

(February 2020)

©2019 The College of Psychiatric and Neurologic Pharmacists (CPNP) and the National Alliance on Mental Illness (NAMI). CPNP and NAMI make this certificate available under the Creative Commons Attribution-No Derivatives 4.0 International License. Last Updated: January 2016.

This information is beingness provided as a community outreach effort of the Higher of Psychiatric and Neurologic Pharmacists. This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. E'er seek the advice of a medico or other qualified medical professional with any questions yous may take regarding medications or medical conditions. Never filibuster seeking professional medical advice or disregard medical professional person communication equally a outcome of whatsoever data provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a consequence of the information provided herein.